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. 2022 May 10;13:2563. doi: 10.1038/s41467-022-30190-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The top rectangles represent a schematic diagram of the linearized HPV16 genome structure. The solid lines below the virus genome represent the DNA fragment of HPV that was integrated into the human genome in each clonal integration event. The dot at the line end represents the breakpoint in the viral genome. The line/dot color represents a respective type of integrated HPV DNA segments as follows: Black, Type A; Blue, Type B; Red, Type C; and Green, Type D. The note of “Amp” on the lines indicates that these DNA fragments are amplified in the clonal integration event. If there was more than one event in a sample, a designation “en” is added after the sample name to distinguish these events, where n codes 1 to number of events. Only HPV16-related clonal integration events are shown. Source data are provided as a Source Data file.