Fig. 1. Representative depiction of the GPCR pocketome.

Cumulative densities for all class A GPCRs (orange volumes) are shown projected on the structure with PDB 1F88 ([10.2210/pdb1F88/pdb]; ice blue ribbon). The surface is indicated white transparent. Visible hotspots (pockets) located at the lipid-facing receptor portion around the 7TM bundle are labelled either as OS (Orphan Site) or KS (Known Site). A more detailed description of their location is provided in the text and Table 1. We note that OS3 was described in the most recent X-ray structure PDB 7M3J⁶⁴ [10.2210/pdb7M3J/pdb] during writing of this manuscript. We therefore re-labelled this site to KS12. Furthermore, OS4 was not found in the class A densities. Three known and three orphan pockets (red labels) are discussed in more detail in the text. The red sphere indicates the tip of HVIII and has been included for ease of orientation. Source data are provided as a source_data.xlsx file.