TABLE 1.
Summary of role of cholesterol in HH protein transportation.
| References | Nature of role |
|---|---|
| The et al. (1999) | Interaction of hedgehog and HSPG requires hedgehog cholesterol modification |
| Callejo et al. (2006) | Hedgehog lipid modifications are required for hedgehog protein stabilization |
| Kenwrick et al. (2019) | Hedgehog without cholesterol modification does not interact properly with Shifted |
| Dawber et al. (2005) | Hedgehog without cholesterol modification has a decreased affinity for plasma membrane |
| Lewis et al. (2001) | Cholesterol modification of hedgehog is required for long-range signaling activity |
| Stewart et al. (2018) | Dispatched actively regulates the levels of cholesterol-modified hedgehog ligand |
| Wierbowski et al. (2020) | Dispatched and scube mediate the secretion of the cholesterol-modified hedgehog |
| Cannac et al. (2020) | Dispatched dedicates to the release of cholesterol-modified hedgehog |
| Rohatgi et al. (2009) | Normal sterol concentrations are required for proper activation of Smoothened |
| Byrne et al. (2016) | Oxysterols are allosteric activators of the oncoprotein Smoothened |
| Huang et al. (2016) | Hedgehog signaling controls Smoothened by regulating its access to cholesterol |
| Luchetti et al. (2016), Xiao et al. (2017) | Cholesterol influences Hedgehog signaling by directly activating Smoothened |
| Kowatsch et al. (2019) | The regulation of Smo by Ptc1 is thought to be dependent on cholesterol |