TABLE 3.
Summary of role for HH in steroid-associated organs and steroid metabolisms.
| References | Nature of role |
|---|---|
| Tang et al. (2015b) | The activation of Hh signaling triggers conversion of cholesterol to progesterone and estradiol |
| Finco et al. (2015) | Hedgehog signaling pathway is important in steroidogenesis of endocrine tissues |
| Finco et al. (2018) | Excessive activation of Hh signal affects vascular development in mice |
| Albert et al. (2018) | The SHH pathway proteins show particular spatiotemporal expression patterns during adrenals development |
| Takai et al. (2019) | Hh signalling is required for maintenance of somatic cyst stem cells in the Drosophila testis |
| Zhu et al. (2016) | Shh/Gli2 and Shh/Gli3 signals are required for murine placentas development |
| Matz-Soja et al. (2016) | HH signaling is crucial for the human pregnancy maintenance and fetal development |
| Rennert et al. (2017) | The Hh pathway plays a pivotal role in hepatic steatosis |
| Luo et al. (2020) | The hepatocyte-specific deletion of Smo induces steroidogenesis and results in an impaired hormonal balance |