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. 2022 Apr 27;12:869417. doi: 10.3389/fonc.2022.869417

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Copyright © 2022 Aaltonen, Kyykallio, Tollis, Capra, Hartikainen, Matilainen, Oikari and Rilla

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pericellular hyaluronan promotes the coordination of cell motion in cancer cells. Comparison of live MCF10CA control cells (A–C) and hyaluronidase-digested cells (D–F) stained with FITC-labeled CD9 and fHABC. Blue = nuclei. Whisker and box plot showing the distribution of correlation index (CI) for untreated (left) and hyaluronan-degrading enzyme-treated (right) cancer cells (G). Plots were constructed using data from 25 and 20 FOVs from 4 experiments for each condition respectively, totalizing several hundreds of cells. The CI for each FOV was normalized to the median CI of untreated cells for the same experiment. **: Wilcoxon rank-text p-value p=0.0068.