Fig. 1. Structures of molecules (A) superimposed structures of EGFR kinase with three ligands are shown in cartoon modes. The main domains of EGFR (hinge region, C-helix, A-loop, and P-loop) are colored with green. (B) Binding pocket of EGFR kinase is displayed in surface modes. Structures of three ligands are shown in stick modes: (C) TAK-285, (D) W2P, and (E) HKI-272.
