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. 2018 Dec 3;8(70):40061–40163. doi: 10.1039/c8ra07325b

The effect of various Lewis acids.

Entry RX Lewis acid Product Yield [%]
1a 282 ZnCl2 283 99
2a 279 ZnCl2 541
3b 279 AgOTf 541 81
4a 540 ZnCl2 542 Tracec
5b 540d AgOTf 542
a

Reaction condition: ZnCl2 (10 equiv.), RX (2 equiv.), Et2O, 0 °C.

b

Reaction condition: AgOTf (4 equiv.), RX (3 equiv.), THF, −78 °C.

c

Complex mixture.

d

540 two equivalents. Reaction temperature: −78 to 0 °C.