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. 2022 Apr 27;13:881658. doi: 10.3389/fphys.2022.881658

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Copyright © 2022 Valerianova, Mlcek, Grus, Malik and Kittnar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The acute effects of high-flow AVF on systemic hemodynamics. Opening of a high-flow arteriovenous fistula increases cardiac output (CO) and coronary blood flow at cost of perfusion of other vascular beds (brain, kidneys, peripheral tissues). We did not measure gut perfusion, but it could be influenced too. Increase in CO leads to increase in pulmonary artery pressure. High resistant beds refer to arteries supplying extremities and other striated muscles. Arrows indicate increase/decrease of blood flow.