Table 5.
The COX Proportional Hazards Model Analyses Predictors for OS
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | 0.974 (0.926–1.024) | 0.2986 | 1.046 (0.930–1.177) | 0.4506 |
| Gender | ||||
| Male | 1.003 (0.469–2.144) | 0.9949 | 0.784 (0.200–3.068) | 0.7267 |
| Female | ||||
| ECOG | ||||
| 1–2 | ||||
| 3–4 | 1.228 (0.700–2.155) | 0.4730 | 0.984 (0.307–3.154) | 0.9777 |
| Smoking | ||||
| Yes | 1.155 (0.667–2.000) | 0.6063 | 1.660 (0.743–3.705) | 0.2163 |
| No | ||||
| Hypertension | ||||
| Yes | 0.636 (0.365–1.107) | 0.1091 | 0.612 (0.279–1.341) | 0.2200 |
| No | ||||
| CHD | ||||
| Yes | 0.628 (0.357–1.104) | 0.1061 | 0.401 (0.108–1.482) | 0.1705 |
| No | ||||
| Chemotherapy | ||||
| Yes | 1.031 (0.591–1.798) | 0.9148 | 0.967 (0.463–2.016) | 0.9279 |
| No | ||||
| Radiotherapy | ||||
| Yes | 0.893 (0.457–1.742) | 0.7389 | 1.801 (0.629–5.152) | 0.2728 |
| No | ||||
| ACCI | 1.402 (1.226–1.604) | <0.001 | 1.456 (1.162–1.824) | 0.0011 |
| HbA1c | 1.009 (0.756–1.346) | 0.9540 | 0.805 (0.567–1.143) | 0.2248 |
| CEA | 1.006 (1.001–1.011) | 0.0234 | 1.008 (0.992–1.024) | 0.3192 |
| Alb | 0.992 (0.945–1.042) | 0.7529 | 1.008 (0.944–1.076) | 0.8097 |
Abbreviations: ACCI, the age-adjusted Charlson comorbidity index; ECOG, Eastern Cooperative Oncology Group Performance Status; CHD, coronary heart disease; CEA, carcino-embryonic antigen; HbA1c, glycosylated hemoglobin type A1c; Alb, albumin.