Table 6.
The COX Proportional Hazards Model Analyses Predictors for PFS
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | 0.963 (0.914–1.016) | 0.1693 | 1.027 (0.908–1.162) | 0.6667 |
| Gender | ||||
| Male | 0.920 (0.430–1.965) | 0.8290 | 0.576 (0.142–2.339) | 0.4404 |
| Female | ||||
| ECOG | ||||
| 1–2 | ||||
| 3–4 | 1.220 (0.687–2.166) | 0.4967 | 1.181 (0.376–3.712) | 0.7757 |
| Smoking | ||||
| Yes | 1.191 (0.683–2.077) | 0.5376 | 1.691 (0.776–3.683) | 0.1862 |
| No | ||||
| Hypertension | ||||
| Yes | 0.619 (0.352–1.091) | 0.0971 | 0.641 (0.292–1.411) | 0.2695 |
| No | ||||
| CHD | ||||
| Yes | 0.597 (0.335–1.065) | 0.0807 | 0.440 (0.132–1.468) | 0.1816 |
| No | ||||
| Chemotherapy | ||||
| Yes | 1.092 (0.621–1.921) | 0.7600 | 1.052 (0.499–2.218) | 0.8944 |
| No | ||||
| Radiotherapy | ||||
| Yes | 0.904 (0.461–1.772) | 0.7680 | 1.587 (0.538–4.680) | 0.4027 |
| No | ||||
| ACCI | 1.387 (1.212–1.587) | <0.001 | 1.353 (1.085–1.688) | 0.0073 |
| HbA1c | 1.062 (0.800–1.410) | 0.6769 | 0.917 (0.664–1.306) | 0.6325 |
| CEA | 1.004 (0.999–1.010) | 0.1465 | 1.006 (0.988–1.024) | 0.5241 |
| Alb | 0.994 (0.944–1.045) | 0.8022 | 1.004 (0.942–1.071) | 0.8960 |
Abbreviations: ACCI, the age-adjusted Charlson comorbidity index; ECOG, Eastern Cooperative Oncology Group Performance Status; CHD, coronary heart disease; HR, hazard ratio; CI, confidence interval; CEA, carcino-embryonic antigen; HbA1c, glycosylated hemoglobin type A1c; Hb, hemoglobin; Alb, albumin.