Fig. 2. Anti-MDR activity of iso-PXA in vitro. (a) Cytotoxicity of iso-PXA on 21 types of human cancer cell lines and 2 types of human normal tissue cell lines was determined by WST-1 assay. Data are the means ± SD of at least three independent experiments. (b) Cytotoxicity of iso-PXA on HeLa/VCR and HeLa cells was determined by WST-1 assay. Data are the means ± SD of at least three independent experiments. (c) Cytotoxicity of iso-PXA on HeLa/VCR and HeLa cells was determined by RTCA software. (d) Average resistance index of iso-PXA and references on the basis of the cytotoxic activity of agents against HeLa/VCR and HeLa cells, and HeLa/DDP and HeLa cells.
