Figure 3.

Low educational attainment effect on outcomes by mediators in GCKD cohort study participants included in the current analyses. The mediation model aims to evaluate the mediators between low educational attainment and outcomes, after adjustment for age, sex, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio. The percentages describe the proportion which is mediated by each mediator with respect to the total effect of low educational attainment on outcomes. The percentage is calculated by dividing the average casual mediation effects by the total effect (direct and indirect effects of low educational attainment on outcomes). For example, the mediated effect of low educational attainment on death by smoking status was 21%. Each mediator was analyzed separately, and therefore estimates of proportion mediated do not take into account potential overlapping mediation effects. (a) Mediated effect of low educational attainment on death. (b) Mediated effect of low educational attainment on MACE. CRP, C-reactive protein; CVD, cardiovascular disease; GCKD, German Chronic Kidney Disease; MACE, major adverse cardiovascular event.