TABLE 4.
Pooled results on the association between the TP53 IVS6+62A > G (rs1625895) polymorphism and BC risk.
| Variable | n (Cases/Controls) | CG vs. CC | GG vs. CC | GG + CG vs. CC | GG vs. CC + CG | G vs. C | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P h/I 2 (%) | BFDP | OR (95%CI) | P h/I 2 (%) | BFDP | OR (95%CI) | P h/I 2 (%) | BFDP | OR (95%CI) | P h/I 2 (%) | BFDP | OR (95%CI) | P h/I 2 (%) | BFDP | |||
| Overall | 25 (12,222/12,895) | 1.01 (0.89, 1.14) a | <0.001/61.6 | – | 0.93 (0.79, 1.11) | 0.180/20.4 | – | 1.00 (0.89, 1.14) a | <0.001/65.0 | – | 0.95 (0.81, 1.12) | 0.542/0.0 | – | 1.00 (0.90, 1.11) a | <0.001/62.7 | – | |
| Matching | |||||||||||||||||
| No/NR | 12 (5,551/5,024) | 0.91 (0.72, 1.14) a | <0.001/73.7 | – | 0.84 (0.55, 1.29) a | 0.045/45.0 | – | – | <0.001/75.6 | – | 0.96 (0.76, 1.22) | 0.267/18.0 | – | 0.92 (0.77, 1.10) a | <0.001/73.0 | – | |
| Yes (include Age) | 13 (6,671/7,871) | 1.06 (0.98, 1.15) | 0.139/30.6 | – | 0.96 (0.76, 1.21) | 0.604/0.0 | – | 1.08 (0.95, 1.23) a | 0.057/41.7 | – | 0.94 (0.75, 1.19) | 0.689/0.0 | – | 1.06 (0.94, 1.20) a | 0.043/44.2 | – | |
| Blinding and/or quality control | |||||||||||||||||
| No | 14 (2,908/2,658) | 0.87 (0.64, 1.18) a | <0.001/71.4 | – | 0.80 (0.49, 1.31) a | 0.085/36.4 | – | 0.86 (0.63, 1.17) a | <0.001/74.1 | – | 0.90 (0.67, 1.22) | 0.381/6.4 | – | 0.89 (0.70, 1.13) a | <0.001/71.8 | – | |
| Yes | 11 (9,314/10,237) | 1.03 (0.96, 1.11) | 0.104/36.9 | – | 0.98 (0.80, 1.20) | 0.514/0.0 | – | 1.05 (0.95, 1.16) a | 0.078/40.7 | – | 0.97 (0.80, 1.19) | 0.565/0.0 | – | 1.04 (0.95, 1.14) a | 0.078/40.6 | – | |
| HWE | |||||||||||||||||
| In violation | 4 (4,624/6,185) | 1.03 (0.94, 1.14) | 0.128/47.3 | – | 0.79 (0.59, 1.05) | 0.869/0.0 | – | 1.01 (0.92, 1.11) | 0.115/49.4 | – | 0.79 (0.59, 1.05) | 0.890/0.0 | – | 0.99 (0.91, 1.08) | 0.131/46.7 | – | |
| Compliant | 21 (7,598/6,710) | 1.00 (0.85, 1.18) a | <0.001/64.6 | – | 1.02 (0.83, 1.26) | 0.123/27.1 | – | 1.00 (0.85, 1.18) a | <0.001/68.0 | – | 1.05 (0.86, 1.29) | 0.482/0.0 | – | 1.00 (0.87, 1.15) a | <0.001/65.9 | – | |
| Source of control | |||||||||||||||||
| PB | 13 (6,801/6,958) | 1.06 (0.92, 1.21) a | 0.044/44.2 | – | 0.90 (0.72, 1.13) | 0.725/0.0 | – | 1.05 (0.91, 1.21) a | 0.028/47.7 | – | 0.92 (0.74, 1.14) | 0.783/0.0 | – | 1.02 (0.91, 1.15) a | 0.051/42.7 | – | |
| BV | 4 (1,882/1,692) | 1.04 (0.73, 1.46) a | 0.011/73.1 | – | 1.74 (1.05, 2.91) | 0.549/0.0 | 0.997 | 1.07 (0.76, 1.51) a | 0.009/74.1 | – | 1.73 (1.04, 2.88) | 0.598/0.0 | 0.997 | 1.08 (0.80, 1.46) a | 0.013/72.2 | – | |
| HB | 3 (2,871/3,583) | – | <0.001/92.0 | – | – | 0.010/78.1 | – | – | <0.001/93.2 | – | 0.75 (0.52, 1.08) | 0.154/46.5 | – | – | <0.001/92.8 | – | |
| NR | 5 (668/662) | 1.09 (0.83, 1.41) | 0.424/0.0 | – | 1.08 (0.59, 1.99) | 0.670/0.0 | – | 1.08 (0.84, 1.39) | 0.454/0.0 | – | 1.03 (0.57, 1.88) | 0.669/0.0 | – | 1.06 (0.85, 1.32) | 0.531/0.0 | – | |
| Ethnicity | |||||||||||||||||
| African | 1 (16/30) | 3.25 (0.75, 14.02) | – | – | 0.71 (0.03, 18.60) | – | – | 2.89 (0.68, 12.35) | – | – | 0.35 (0.02, 7.64) | – | – | 1.37 (0.56, 3.32) | – | – | |
| Asian | 1 (83/268) | 1.02 (0.44, 2.37) | – | – | 0.46 (0.02, 8.91) | – | – | 0.91 (0.40, 2.09) | – | – | 0.45 (0.02, 8.88) | – | – | 0.83 (0.37, 1.83) | – | – | |
| Caucasian | 19 (10,552/11,861) | 1.01 (0.88, 1.15) a | <0.001/68.0 | – | 0.94 (0.70, 1.25) a | 0.051/37.4 | – | 1.00 (0.87, 1.15) a | <0.001/71.4 | – | 0.94 (0.78, 1.13) | 0.253/16.5 | – | 1.00 (0.88, 1.12) a | <0.001/70.8 | – | |
| Indian | 3 (993/346) | 0.99 (0.70, 1.40) | 0.144/48.5 | – | 0.96 (0.49, 1.89) | 0.604/0.0 | – | 1.01 (0.73, 1.40) | 0.187/40.3 | – | 1.07 (0.66, 1.75) | 0.933/0.0 | – | 1.02 (0.80, 1.32) | 0.390/0.0 | – | |
| Mixed | 1 (578/390) | 1.05 (0.78, 1.41) | – | – | 1.07 (0.46, 2.49) | – | – | 1.05 (0.79, 1.40) | – | – | 1.05 (0.45, 2.45) | – | – | 1.05 (0.81, 1.35) | – | – | |
| Geographic region | |||||||||||||||||
| Asia | 9 (1,528/1,057) | 0.76 (0.48, 1.22) a | <0.001/72.8 | – | 0.71 (0.47, 1.06) | 0.141/34.6 | – | – | <0.001/75.1 | – | 0.84 (0.59, 1.20) | 0.578/0.0 | – | 0.82 (0.59, 1.15) a | <0.001/71.6 | – | |
| Europe | 11 (8,369/9,417) | 1.05 (0.94, 1.18) a | 0.036/48.3 | – | 1.05 (0.84, 1.30) | 0.305/14.6 | – | 1.05 (0.94, 1.18) a | 0.035/48.5 | – | 1.04 (0.83, 1.29) | 0.326/12.4 | – | 1.05 (0.95, 1.16) a | 0.045/46.3 | – | |
| North America | 5 (2,325/2,421) | 1.09 (0.75, 1.58) a | 0.023/64.7 | – | 0.85 (0.58, 1.23) | 0.447/0.0 | – | 1.09 (0.74, 1.62) a | 0.010/70.1 | – | 0.85 (0.59, 1.24) | 0.508/0.0 | – | 1.06 (0.76, 1.49) a | 0.010/69.7 | – | |
| ER status | |||||||||||||||||
| Negative | 2 (121/300) | 0.72 (0.39, 1.32) | – | – | 3.59 (0.32, 40.14) | – | – | 0.78 (0.43, 1.41) | – | – | 8.60 (2.97, 24.91) | 0.430/0.0 | 0.961 | 0.87 (0.51, 1.49) | – | – | |
| Positive | 2 (243/300) | 1.23 (0.78, 1.94) | – | – | 3.13 (0.32, 30.42) | – | – | 1.27 (0.81, 2.00) | – | – | 10.32 (4.31, 24.72) | 0.224/32.4 | 0.265 | 1.27 (0.84, 1.92) | – | – | |
| Tumor grade | |||||||||||||||||
| Grade I | 2 (79/796) | 1.23 (0.65, 2.31) | – | – | 0.71 (0.09, 5.46) | – | – | 1.17 (0.63, 2.17) | – | – | – | 0.009/85.5 | – | 1.10 (0.63, 1.90) | – | – | |
| Grade II | 2 (95/796) | 0.92 (0.48, 1.78) | – | – | 0.30 (0.02, 5.04) | – | – | 0.82 (0.42, 1.58) | – | – | – | 0.002/89.4 | – | 0.74 (0.40, 1.38) | – | – | |
| Grade III | 2 (80/796) | 0.94 (0.47, 1.88) | – | – | 0.69 (0.09, 5.33) | – | – | 0.92 (0.47, 1.78) | – | – | – | 0.025/80.1 | – | 0.90 (0.49, 1.64) | – | – | |
| Menopausal status | |||||||||||||||||
| Postmenopausal | 3 (382/240) | 0.65 (0.30, 1.41) a | 0.139/54.3 | – | 0.98 (0.19, 5.15) | 0.833/0.0 | – | 0.68 (0.33, 1.39) a | 0.156/50.3 | – | 3.27 (0.47, 22.62) a | 0.035/70.2 | – | 0.79 (0.52, 1.19) | 0.219/33.9 | – | |
| Premenopausal | 3 (201/270) | 1.20 (0.72, 2.01) | 0.631/0.0 | – | 3.00 (0.59, 15.30) | 0.624/0.0 | – | 1.30 (0.79, 2.15) | 0.678/0.0 | – | 7.30 (1.54, 34.58) a | 0.134/50.3 | 0.998 | 1.36 (0.87, 2.14) | 0.730/0.0 | – | |
| Age | |||||||||||||||||
| <50 years | 2 (513/528) | 0.57 (0.41, 0.78) | – | 0.924 | 0.62 (0.26, 1.53) | – | – | 0.58 (0.42, 0.78) | – | 0.900 | – | <0.001/95.0 | – | 0.62 (0.47, 0.82) | – | 0.954 | |
| ≥50 years | 2 (1058/961) | 1.02 (0.82, 1.27) | – | – | 1.05 (0.57, 1.94) | – | – | 1.02 (0.82, 1.26) | – | – | – | <0.001/95.1 | – | 1.02 (0.84, 1.23) | – | – | |
| Sensitivity analysis | |||||||||||||||||
| Overall | 6 (4,341/3,983) | 1.01 (0.91, 1.11) | 0.338/12.0 | – | 1.07 (0.79, 1.44) | 0.580/0.0 | – | 1.01 (0.92, 1.12) | 0.282/20.1 | – | 1.07 (0.80, 1.44) | 0.625/0.0 | – | 1.01 (0.93, 1.11) | 0.268/22.1 | – | |
| Ethnicity | |||||||||||||||||
| Caucasian | 5 (3,763/3,593) | 1.00 (0.90, 1.11) | 0.233/28.4 | – | 1.07 (0.78, 1.47) | 0.435/0.0 | – | 1.00 (0.90, 1.12) | 0.187/35.2 | – | 1.07 (0.78, 1.47) | 0.480/0.0 | – | 1.01 (0.92, 1.11) | 0.174/37.0 | – | |
| Mixed | 1 (578/390) | 1.05 (0.78, 1.41) | – | – | 1.07 (0.46, 2.49) | – | – | 1.05 (0.79, 1.40) | – | 1.05 (0.45, 2.45) | – | – | 1.05 (0.81, 1.35) | – | – | ||
| Geographic region | |||||||||||||||||
| Europe | 5 (3,763/3,593) | 1.00 (0.90, 1.11) | 0.233/28.4 | – | 1.07 (0.78, 1.47) | 0.435/0.0 | – | 1.00 (0.90, 1.12) | 0.187/35.2 | – | 1.07 (0.78, 1.47) | 0.480/0.0 | – | 1.01 (0.92, 1.11) | 0.174/37.0 | – | |
| North America | 1 (578/390) | 1.05 (0.78, 1.41) | – | – | 1.07 (0.46, 2.49) | – | – | 1.05 (0.79, 1.40) | – | – | 1.05 (0.45, 2.45) | – | – | 1.05 (0.81, 1.35) | – | – | |
a
Random-effects model was used in the pooled data.
Note: The bold values indicate significant results.