Table 2.

Schedule of Patient Enrollment, Study Interventions, and Endpoint Measurements

	Study Period
	Enrollment	Allocation	Post-Allocation			Close-Out
Timepoint	Anesthesia Clinic Visit	Prior to Sedation	During Sedation	Emergence from Sedation	15 Min in Recovery Room	Hospital Discharge
Patient enrollment
Inclusion criteria	×
Exclusion criteria	×
Written informed consent	×
Demographic data	×
Baseline characteristics	×
Randomization		×
Allocation		×
Study interventions
Esketamine			×
Normal saline placebo			×
Endpoint measurements
Desaturation events			×
Hypotension events			×
Total dose of propofol			×
NRS pain scores				×	×
NRS fatigue scores				×	×
Dizziness				×	×	×
Hallucination or nightmare				×	×	×
Nausea and vomiting				×	×	×
Endoscopist satisfaction			×
Patient satisfaction					×

Abbreviation: NRS, numerical rating scale.