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. 2022 May 6;17:2069–2078. doi: 10.2147/IJN.S362418

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© 2022 Liang et al.

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The in vivo tumoral uptake of Lec(RSV) nanoparticle. (A) BT474 orthotopic model was used to carry out in vivo tumoral uptake experiment. We treated one group of female Balb/C nude mice (n = 3) with Lec(RSV + FITC) NPs for 1 hour and another group (n = 3) for 4 hours. The red circles indicate the accumulation effects of the nanoparticles in the tumor at 1 hour and 4 hours after injection. It shows that the tumoral uptake of Lec(RSV) was significantly increased in the tumor after 4 hours compared to the 1-hour group, indicating the reliability of Lec(RSV) to be used as a drug delivery system for the treatment of cancer. (B) TUNEL assay analysis of the tumor section in (A). At 4 hours, the tumors treated with Lec(RSV) indicated higher apoptosis level as compared to the tumors treated only for 1 hour, indicated prolonged effect of tumor killing effect of Lec(RSV). Scale bar indicated 50 µm.