Fig. 6.

In situ repair abilities of human UC-MSCs on ovarian hypofunction caused by natural aging in rhesus monkeys with advanced age. A FISH analysis for tracking transplanted HuMSCs in the ovaries. B The hormone levels of FSH and E₂ were measured by CLIA test at pre- or post-treatment in the control group and HuMSCs-treated group; ↑ shows rising tendency and ↓ shows dropping amplitude compared with pre-treatment, ^##P < 0.01 vs. pre-treatment, **P < 0.01 vs. the control group. C Representative images of ovarian morphology with HE-staining (Scale bar = 200 μm) and the comparison for total number of follicles. *P < 0.05, **P < 0.01,^#’#’P < 0.01 vs. Young-Control; ^#P < 0.05 vs. Control Group; ns: no statistical differences (vs. Control Group). D The comparison for the number of follicles at all levels. *P < 0.05, **P < 0.01, ^#’P < 0.05 vs. Young-Control; ^#P < 0.05 vs. Control Group. E Representative image of mitochondrial ultramicrostructure detected by TEM (Scale bar = 1 μm); White square represents low power of mitochondria (Scale bar = 2 μm).