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. 2022 Feb 14;7(5):1027–1036. doi: 10.1016/j.ekir.2022.02.002

Table 2.

Independent associations between urinary levels of AP and CP/LP activation fragments and terminal pathway C5a

Standardized β P
Focal and segmental glomerulosclerosis, r2: 0.52
 Ba 0.59 0.003
 C4a 0.36 0.047
Membranous nephropathy, r2: 0.86
 Ba 0.67 <0.001
 C4a 0.48 <0.001
IgA nephropathy, r2: 0.89
 Ba 0.73 <0.001
 C4a 0.31 <0.001
Lupus nephritis, r2: 0.83
 Ba 0.72 <0.001
 C4a 0.35 0.009
ANCA-associated vasculitis, r2: 0.71
 Ba 0.21 0.13
 C4a 0.77 <0.001

ANCA, antineutrophil cytoplasmic autoantibody; AP, alternative pathway; CP, classical pathway; LP, lectin pathway.

C4a and Ba correspond to CP/LP and AP activation fragments, respectively.