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. 2018 Dec 12;8(72):41536–41547. doi: 10.1039/c8ra08260j

Effect of various solvents on the reaction time and yield of 1,4-disubstituted-1,2,3-triazole 8a upon using Cu(ii)/NP.

graphic file with name c8ra08260j-u1.jpg
Entry Solvent Time (min) Isolated yield 8a (%)
1 H2O 60 10
2 EtOH 60 90
3 MeOH 15 95
4 CH2Cl2 120 25
5 CH3CN 90 20
6 CH3OAc 120 5
7 THF 90 80
8 1,4-Dioxane 120 5