FIGURE 2.
Plasma proteomic signatures associated with moderate/severe diffusion impairment and D LCO levels in survivors of ARDS secondary to SARS‐CoV‐2 infection. (A) Proteins are ranked by their variable importance to component 1. (B) Supervised component analysis cluster through sparse partial least‐squares discriminant analysis (sPLS‐DA) discriminating between survivors with moderate/severe diffusion impairment (DLCO < 60%) and survivors with mild or an absence of alterations in diffusion capacity survivors (DLCO≥60%). Each point represents a patient. (C) Receiver operating characteristic (ROC) curve for the protein signature. The discriminative power of the signature is represented as the area under the ROC curve (AUC). (D) Proteins ranked by their variable importance for component 1. (E) Supervised component analysis cluster through sPLS according to the D LCO levels of the cohort. Each protein represents a survivor. (F) Generalized additive model (GAM) with penalized cubic regression splines for D LCO (Y axis) and the first component (X axis). The significance of the association is given by the coefficient of determination (R 2)