FIGURE 4.

Comparison of SARS‐CoV‐2‐specific immune response between naïve and COVID‐19‐recovered individuals according to their vaccination regimen. (A) The comparison of plasmatic anti‐spike RBD IgG levels in naïve and COVID‐19‐recovered individuals for the different vaccination strategies is shown. (B) The comparison of plasmatic neutralizing antibodies levels in naïve and COVID‐19‐recovered individuals for the different vaccination strategies is shown. (C) The comparison of Spike SARS‐CoV‐2‐specific CD4⁺ proliferation in naïve and COVID‐19‐recovered individuals for the different vaccination strategies is shown. *p < .05; **p < .01; ***p < .001; ****p < .0001 in Kruskal–Wallis with Dunn's multiple post‐hoc test and Mann–Whitney test for three or two group comparisons, respectively