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. 2022 Apr 27;13:889226. doi: 10.3389/fphar.2022.889226

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Copyright © 2022 Duan, Wang, Jiao, Geng, Wu, Yan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo experimental procedures and neurological function evaluation. (A) Graphical abstract of the in vivo study. (B) The coronal sections of the brain tissue were prepared following sucrose dehydration (5 mm), to evaluate intracranial hematoma. (C) The cerebral water content was measured 3 and 7 d after ICH. (D) The reduction in the hematoma volume is reported as a percentage. (E) Statistical analysis of the corner turn test. (F) The mNSS score of rats in each group. The data are shown as the means ± SD of n = 3 samples/group and at least three independent experiments were performed. Statistical analyses were conducted using two-way ANOVA. Compared with ICH group, *, p < 0.01 and **, p < 0.01. Compared with ICH + Curcumin group, ★, p < 0.01.