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. Author manuscript; available in PMC: 2023 Nov 4.
Published before final editing as: ACS Nano. 2022 May 4:acsnano.2c02794. doi: 10.1021/acsnano.2c02794

Fig. 6. Variable uptake of “pseudovirus-like” nanoparticles by leukocytes in lepirudin blood.

Fig. 6.

A) blood donors with high and low anti-RBD titers measured with the microbead assay (mean of triplicate run); B) RBD-dependent C3 deposition in lepirudin plasma (mean and SD of triplicate); C) uptake of nanoparticles (mean fluorescence intensity) by total leukocytes and effect of sCR1 in 4 blood donors. D) Flow analysis of uptake by leukocytes in blood from donor F61. Ly=lymphocytes; Mo=monocytes; Gr=granulocytes; E) uptake efficiency by different leukocyte types (determined from FSC/SSC plots) in 2 donors with high anti-RBD titers.