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. 2022 Apr 27;13:782684. doi: 10.3389/fphys.2022.782684

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Copyright © 2022 Eid, Dzreyan and Demyanenko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT1 levels in the astrocytes of ischemic penumbra 4 and 24 h after photothrombotic stroke in the rat cerebral cortex (PTS4 and PTS24, respectively) compared to the same animals’ contralateral cortex (CL4 and CL24), or the cortex of sham-operated animals (SO). (A) Immunofluorescence of SIRT1 (green), marker of astrocytes GFAP (red), nuclear chromatin marker Hoechst 33342 (blue), and image overlay. The scale bar is 100 μm. (B) Coefficient M1 of SIRT1 co-localization with astrocyte marker (GFAP) in different control and experimental groups. One Way ANOVA; M ± SEM; n = 7.