Figure 1.

Clinical presentation of patients with CSNK2B variants

Front and side views of subjects 1–3 diagnosed with IDCS show strikingly similar facial gestalt, whereas subjects 4 and 5 diagnosed with POBINDS show vivid difference of facial gestalt, and no obvious digital or limb anomaly was recorded as in IDCS. Digital anomalies of IDCS patients are shown in two panels on right side. For subject 1, arrows show brachydactyly 2–5 and syndactyly 2–3 of the digits of the feet. Notably, preoperative radiographs of the hands and teeth are shown for subject 1.