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Graphical summary. eCIRP binds to TREM-1. eCIRP increases TREM-1 expression and activates its downstream molecules DAP12 and Syk in neutrophils, which lead to the increased expression of ICAM-1 and activation of Rho. eCIRP-induced Rho activation ultimately leads to increased NET formation. Targeting TREM-1-eCIRP interaction with LP17 which is a decoy peptide of TREM-1 inhibits eCIRP-TREM-1-mediated expression of ICAM-1 in the neutrophils and subsequently attenuating NET formation
