Table 4.
Characteristics of patients who never developed viremia
Patient number | Indication for transplant | Conditionin gintensity | GVHD prophylaxis | EBV and CMV serostatus (donor/recipient) | Serotherapy | Transplant day at infusion | Status at last follow-up |
---|---|---|---|---|---|---|---|
2 | AML | MAC MRD Marrow | Tacrolimus, MTX | CMV: −/+ EBV: −/+ | None | 21 | Alive |
3 | Severe aplastic anemia | RICM UDP BSC | T-cell depletion | CMV: −/+ EBV: −/+ | Alemtuzumab | 22 | Alive |
8 | HLH | RICM UDP BSC | CSA, prednisone | CMV: +/− EBV: +/+ | Alemtuzumab | 39 | Alive |
13 | ALL | MAC MUD Marrow | CSA, MMF, abatacept | CMV: −/+ EBV: +/+ | None | 24 | Dead, relapse, day 143 |
16 | Hgb SD | RIC MRD Marrow | CSA, MTX, abatacept | CMV: −/− EBV: −/− | Alemtuzumab | 22 | Alive |
19 | ALL | MAC MRD Marrow | CSA, MMF | CMV: +/+ EBV: −/+ | None | 25 | Alive |
28 | AML | RIC MRD PBSC | T-cell depletion | CMV: −/− EBV: +/+ | Ex-vivo depletion only | 24 | Alive, relapse 6 mo after HSCT |
ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CSA, cyclosporine A; Hgb, hemoglobin; HLH, hemophagocytic lymphohistiocytosis; MAC, myeloablative conditioning; MRD, matched related donor; MTX, methotrexate; MUD, matched unrelated donor; PBSC, peripheral blood stem cell; VST, virus-specific T cell.