Fig. 6.

Diversity of the Cβ isoforms. The variability of the Cβ isoforms is determined by exon 1 (right). None of the Cβ isoforms, with the exception of Cβ1, are myristylated, and none have so far been characterized biochemically or at the cellular level. There are only 25 sequence differences between Cα1 and Cβ1 (green dots), and half of these are localized to the tails. The rest are mostly in the N-lobe and in regions that interact with the Nt- or Ct-tail. None are in catalytic residues or near the active site, suggesting the differences between Cα and Cβ will correlate with differences in regulation.