TABLE 1.
Demographic, biomarker data, and minor allele distribution for variants retained in the regression models in each diagnostic group
| Variables | CN (N = 352) | MCI (N = 160) | DEM (N = 54) | P ‐value |
|---|---|---|---|---|
| Age, years, mean (SD) | 73.6 (7.1) | 75.7 (8.2) | 77.4 (9.1) | <.001 |
| Sex, % male | 43.5 | 65.0 | 53.7 | <.001 |
| APOE ε4 alleles, % 0/1/2 | 66/31/3 | 61/28/11 | 43/33/24 | <.001 |
| MMSE, mean (SD) | 29.1 (1.3) | 27.4 (2.5) | 20.2 (6.0) | <.001 |
|
Meta‐ROI flortaucipir SUVR, mean (SD) |
1.48 (0.19) | 1.63 (0.35) | 2.33 (0.77) | <.001 |
| ABCA7 rs3752246, % 0/1/2 | 63/34/4b | 73/26/1 | 63/33/4 | .098 |
| ABCA7 rs3764650, % 0/1a | 80/20 | 85/15 | 85/15 | .334 |
| BIN1 rs6733839, % 0/1/2 | 40/43/17 | 34/52/14 | 35/46/19 | .394 |
| BIN1 rs744373, % 0/1/2 | 49/42/9 | 48/42/10 | 46/46/7b | .968 |
| CASS4 rs7274581, % 0/1a | 85/15 | 81/19 | 83/17 | .627 |
| CLU rs9331949, % 0/1a | 94/6 | 96/4 | 96/4 | .433 |
| CR1 rs12034383, % 0/1/2 | 15/49/36 | 16/48/36 | 9/52/39 | .807 |
| CR1 rs3818361, % 0/1/2 | 68/29/4b | 64/32/4 | 63/35/2 | .757 |
| DSG2 rs8093731, % 0/1a | 97/3 | 98/2 | 98/2 | .869 |
| EPHA1 rs11767557, % 0/1/2 | 66/30/4 | 66/31/3 | 63/35/2 | .913 |
| NME8 rs2718058, % 0/1/2 | 38/48/15b | 41/48/12b | 46/43/11 | .734 |
| SORL1 rs11218343, % 0/1a | 90/11b | 92/8 | 89/11 | .670 |
| ZCWPW1 rs1476679, % 0/1/2 | 51/41/8 | 46/43/11 | 67/32/2b | .050 |
Note: This table shows a demographic, neuropsychological, and imaging measure comparison across each of the diagnostic groups. We also display the percentage of subjects who had each copy number for the genes retained in any of the four regression models. P‐values were generated using ANOVA and Chi‐square where necessary.
aCollapsed because minor allele homozygote frequency was <2%.
bDoes not add up to 100% due to rounding.
Abbreviations: ANOVA, analysis of variance; APOE, apolipoprotein E; CN, cognitively normal; DEM, dementia; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; ROI, region of interest; SD, standard deviation; SUVR, standardized uptake value ratio.