. 2022 May 11;14(1):e12308. doi: 10.1002/dad2.12308

TABLE 2.

Regression results in each diagnostic group

Pooled sample, model R ² = 0.3970/adjusted R ² = 0.3861, P < .0001
Variants selected	Parameter estimate	Standard error	Parameter P‐value/FDR‐corrected P‐value	[¹⁸F]flortaucipir SUVR by risk allele	SUVR P‐value
*APOE* ε4	0.052	0.011	<.0001	1.54/1.64/2.01	<.001
ABCA7 rs3752246	0.024	0.013	.0567/.1395	1.59/1.62/1.81	.097
BIN1 rs6733839	0.014	0.010	.1395/.1395	1.56/1.64/1.62	.100
CR1 rs3818361	0.019	0.012	.1211/.1395	1.59/1.64/1.61	.325
NME8 rs2718058	–0.018	0.010	.0785/.1395	1.66/1.57/1.56	.037
ZCWPW1 rs1476679	–0.017	0.011	.0991/.1395	1.66/1.54/1.58	.007

CN sample, model R ² = 0.0971/adjusted R ² = 0.0840, P < .0001
Variants selected	Parameter estimate	Standard error	Parameter P‐value/FDR‐corrected P‐value	[¹⁸F]flortaucipir SUVR by risk allele	SUVR P‐value
*APOE* ε4	0.0255	0.011	.0195	1.47/1.48/1.65	.014
ABCA7 rs3764650	0.044	0.014	.0028 /.0057	1.46/1.54	.003
CR1 rs12034383	–0.015	0.008	.0799/.0799	1.50/1.49/1.46	.365

MCI sample, model R ² = 0.2108/adjusted R ² = 0.1744, P < .0001
Variants selected	Parameter estimate	Standard error	Parameter P‐value/FDR‐corrected P‐value	[¹⁸F]flortaucipir SUVR by risk allele	SUVR P‐value
*APOE* ε4	0.076	0.020	.0002	1.55/1.76/1.78	<.001
BIN1 rs6733839	0.045	0.020	.0272 /.0464	1.54/1.68/1.68	.037
CASS4 rs7274581	0.074	0.035	.0348 /.0464	1.61/1.74	.065
CLU rs9331949	0.113	0.070	.1091/.1091	1.63/1.81	.206
CR1 rs3818361	0.051	0.024	.0324 /.0464	1.59/1.70/1.80	.099

DEM sample, model R ² = 0.4240/adjusted R ² = 0.3216, P = .0009
Variants selected	Parameter estimate	Standard error	Parameter P‐value/FDR‐corrected P‐value	[¹⁸F]flortaucipir SUVR by risk allele	SUVR P‐value
*APOE* ε4	0.095	0.046	.0455	2.21/2.29/2.60	.332
BIN1 rs744373	–0.177	0.064	.0085 /.0423	2.38/2.37/1.72	.271
CASS4 rs7274581	0.257	0.104	.0176 /.0441	2.27/2.63	.206
DSG2 rs8093731	–0.426	0.276	.1296/.1296	2.35/1.49	.278
EPHA1 rs11767557	0.110	0.071	.1264/.1296	2.23/2.47/2.99	.406
SORL1 rs11218343	–0.208	0.116	.0794/.1296	2.36/2.05	.350

Note: Final results from stepwise linear regression models using 27 AD risk variants, including covariates of age, sex, and APOE ε4 (and diagnosis for pooled model) and log‐transformed outcome measure. Model selection for the risk variants was P = .157.

Abbreviations: AD, Alzheimer's disease; ANOVA, analysis of variance; APOE, apolipoprotein E; CN, cognitively normal; DEM, dementia; FDR, false discovery rate; MCI, mild cognitive impairment; SUVR, standardized uptake value ratio.