Fig. 4.

Effects of neonatal manipulations on D1 receptors labelled with [³H] SCH23390 in basal ganglia nuclei of adolescent and adult male rats. Bar graphs depict specific [³H] SCH23390 binding levels in brain regions of male adolescent (P39–41) and adult (P113–115) control, BMS and PMS rats. Data are presented as mean ± SEM of specific binding expressed in fmol/mg tissue (n = 6–8 adolescent and 8–10 adult rats/group). # Statistically significant manipulation x age interaction (P < 0.05); § statistically significant age effect (P < 0.001; two-way ANOVA with manipulation and age as independent factors). C: control; BMS: brief maternally separated; PMS: prolonged maternally separated rats. CPu: caudate-putamen; NAcC: nucleus accumbens core; NAcS: nucleus accumbens shell; GPi: internal globus pallidus; SN: substantia nigra; * P < 0.05; * *P < 0.01.