Table 5.
Adverse clinical outcomes
(i) Comparison between NfL plasma concentration at day one and change day one to three in patients with hospital lengths of stay of over 14 days who survived 6 months with patients who had a hospital stay of less than 14 days and/or died within 6 months.
(ii) Comparison between NfL plasma concentration at day one in patients who survived up to 6 months and those who died.
| i. | Alive and LOS <14 day (n=38) | Dead or LOS >=14 days (n=104) | Effect size (95 % CI) | p-value |
|---|---|---|---|---|
| Day 1 Concentration pg/ml1 | 38.4 (40.3) | 107.7 (110.8) | 0.34 (0.2,0.5) | <0.0012 |
| Concentration ratio day 3 to day 1 | 1.6 (0.8) | 1.7 (1.2) | 0.93 (0.8, 1.1) | 0.4453 |
| ii. | Alive (n=97) | Dead (n=45) | p-value | |
|---|---|---|---|---|
| Day 1 Concentration pg/ml1 | 65.8 (86.6) | 140.2 (114) | 0.38 (0.3,0.5) | <0.0012 |
| Concentration ratio day 3 to day 1 | 1.6 (1.1) | 1.9 (1.3) | 0.87 (0.7, 1.0) | 0.1453 |
LOS = Length of hospital stay.
1 based on a linear mixed model with log concentration as the outcome and fixed effect for delirium/deep sedation and day (1 or 3) and the interaction between delirium/deep sedation and day with a random effect for the participant including data from day 1 and day 3.
2p-value is the marginal contrast at day 1 and day 3 respectively.
3based on the interaction between delirium/deep sedation and day.