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. 2022 May 10;20:202. doi: 10.1186/s12967-022-03398-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Expression of ISG15 and ZFP36 is increased and decreased in PCa respectively and is correlated with hypoxia. A The expression of ISG15 and ZFP36 increased and decreased respectively in PCa than in paracancerous tissues. B, C The expression of ISG15 and ZFP36 were significantly higher and lower respectively in PC-3, 22RV-1, LNCaP than in RWPE-1 at transcription level and protein level. D–K The expression level of ISG15 and ZFP36 in PC-3,22RV-1 and LNCaP was increased and decreased by the hypoxia at transcription level and protein level. **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. RWPE-1 and 0 h