Table 1.
Classification of novel AKI biomarkers
| Diagnostic utility based on renal injury site | Measurement method | |
|---|---|---|
| Novel sepsis-related AKI biomarkers | ||
| Urine TIMP-2xIGFBP-7 (MW=21 kDa)x(MW=29 kDa) | Tubular injury | Point of Care test |
| Urine NGAL (MW=25 kDa) | Tubular injury | Automated immune turbidimetric assay |
| Urine KIM-1 (MW=39 kDa) | Tubular injury | ELISA |
| Urine Cystatin C (MW=13 kDa) | Tubular injury | Automated immune turbidimetric assay |
| Actin scavenger system proteins | ||
| Urinary actin (MW=42 kDa) | Glomerular and tubular injury | Western blot |
| Serum Gelsolin (MW=83 kDa) | Glomerular injury | Automated immune turbidimetric assay |
| Urine Gc-globulin (MW=52-59 kDa) | Glomerular and tubular injury | Western blot |
Abbreviations: TIMP-2: tissue inhibitor of metalloproteinases-2; IGFBP7: insulin-like growth factor-binding protein 7; NGAL: neutrophil gelatinase-associated lipocalin; KIM-1: kidney injury molecule-1; MW: molecular weight; ELISA: enzyme-linked immunosorbent assay.