TABLE 2.
CIDER dementia risk models—developed in NACC and internally validated based on bootstrapping, externally validated in PROMPT and ADNI
| CIDER MoCA | CIDER MMSE | |
|---|---|---|
| C‐index 95% CI | ||
| Derivation cohort | 0.69 [0.66, 0.73] | 0.67 [0.65, 0.69] |
| Index corrected | 0.69 [0.66, 0.72] | 0.67 [0.65, 0.69] |
| PROMPT | 0.61 [0.59, 0.63] | 0.62 [0.60, 0.64] |
| ADNI | 0.72 [0.69, 0.75] | 0.61 [0.59, 0.63] |
| HR (95% CI) | HR (95% CI) | |
|---|---|---|
| MoCA a | 0.44 [0.37, 0.51] | |
| MMSE b | 0.35 [0.31, 0.40] | |
| Age | 1.23 [1.03, 1.47] | 1.26 [1.17, 1.36] |
| Education | 1.40 [1.14, 1.72] | 1.34 [1.22, 1.47] |
| Sex | ||
| Female vs. male | 0.93 [0.72, 1.20] | 1.11 [1.00, 1.25] |
| Marital status | ||
| Married c vs. others | 1.78 [1.30, 2.43] | 1.46 [1.28, 1.65] |
| Hypertension | ||
| Yes vs. no | 0.78 [0.61, 1.00] | 0.90 [0.81, 1.00] |
| Mood disorder | ||
| Yes vs. no | 1.24 [0.98, 1.56] | 1.43 [1.29, 1.59] |
Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; CI, confidence interval; CIDER, Mild Cognitive Impairment to Dementia Risk; HR, hazard ratio; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; NACC, National Alzheim'r's Coordinating Center; PROMPT, Prospective Registry of Persons with Memory Symptoms.
For MoCA, age, and education years, HRs corresponded to each variable's interquartile range (IQR). For MoCA, IQR = 5; for age, IQR = 11 years; for education, IQR = 5 years; for MMSE, IQR = 3.
MMSE score was modeled using restricted cubic splines (with 3 degrees of freedom).
Married included “married” and “common‐law partnership”.