Table 1.
Characteristics of the included cohort studies
| Study | Design | Country | Diagnosis | Sample size | Mean age (years) | Male (%) | DM (%) | GV measurements and cutoff | Duration for GV measurements (h) | Follow-up duration (days) | No. of patients died | Variables adjusted |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chen 2013 | RC | China | AIS | 72 | 61.7 | 47.2 | 0 | CVBG (30%) | 72 | 28 | 12 | Age and NIHSS at admission |
| Yoo 2014 | RC | Korea | AIS | 207 | 70.6 | 61.4 | 21.3 | SDBG (1.2 mmol/l) | 24 | 90 | 33 | Age, NIHSS at admission, AF, HTN, CAD, smoking and SBP |
| Guo 2015 | RC | China | AHS | 90 | 62.8 | 55.6 | NR | CVBG (50%) | 72 | 28 | 38 | Age, NIHSS at admission, APACHE-II Score, and hypoglycemia |
| Di 2016 | RC | China | AIS and AHS | 176 | 60.3 | 63.6 | 39.8 | CVBG (50%), SDBG (1.2 mmol/l), and MAGE (3.9 mmol/l) | 24 | 90 | 27 | Age, NIHSS at admission, and APACHE-II Score |
| Wang 2018 | RC | China | AIS | 111 | 61.7 | 58.6 | 52.3 | CVBG (30%) and SDBG (1.3 mmol/l) | 24 | 90 | 23 | Age and APACHE-II Score |
| Liu 2019 | RC | China | AIS and AHS | 162 | 58.5 | 54.3 | 42.6 | CVBG (50%) and SDBG (1.3 mmol/l) | 72 | 90 | 30 | Age, NIHSS at admission, and APACHE-II Score |
| Cui 2019 | RC | China | AIS | 107 | 63.5 | 54.2 | 57.9 | CVBG (30%) and SDBG (1.4 mmol/l) | 72 | 28 | 35 | Age and APACHE-II Score |
| Gutiérrez 2020 | RC | Spain | AIS | 213 | 71.2 | 60.1 | 30 | SDBG (median) | 48 | 90 | 16 | Age, NIHSS at admission, and comorbidities |
| Cai 2020 | RC | China | AIS and AHS | 158 | 65.9 | 63.3 | 39.2 | CVBG (50%), SDBG (1.3 mmol/l), and MAGE (median) | 24 | 90 | 24 | Age, NIHSS at admission, APACHE-II Score, and mean BG |
| Chen 2020 | RC | China | AHS | 137 | 60.6 | 66.4 | NR | CVBG (20%) and SDBG (1.4 mmol/l) | 24 | 28 | 42 | Age and APACHE-II Score |
AIS, acute ischemic stroke; AHS, acute hemorrhagic stroke; RC, retrospective cohort; DM, diabetes mellitus; GV, glycemic variability; NR, not reported; AF, atrial fibrillation; HTN, hypertension; CAD, coronary artery disease; AF, atrial fibrillation; SBP, systolic blood pressure; BG, blood glucose; CVBG, coefficient of variation of blood glucose; SDBG, standard deviation of blood glucose; MAGE, mean amplitude of glycemic excursion; NIHSS, National Institute of Health stroke scale; APACHE-II, Acute Physiology and Chronic Health Evaluation II