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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Am J Psychiatry. 2021 Feb 18;178(7):611–624. doi: 10.1176/appi.ajp.2020.20060864

Table 2.

Studies of General Practitioner and Non-Psychiatric Physicians Education

Source Prevention Strategy Length of intervention Population Study Type Location Outcome
Oyama, 2005(15) Educational intervention for nurse depression screening and GP management 8-yrs, screening and depression management Older adults Quasi-experimental* Japan Greater female suicide reduction in intervention region compared with control region (IRR =.35). No regional difference in male suicides.
Oyama, Fujita et. al, 2006(17) Educational intervention for nurse depression screening and GP management 10-yrs, screening and depression management Older adults Quasi-experimental* Japan Greater reduction in intervention region female suicide at a trend level compared with control region (IRR =.23). No regional difference in male suicides.
Oyama, Goto et. al, 2006(16) Educational intervention for nurse depression screening and GP management 10-yrs, screening and Depression management Older adults Quasi-experimental* Japan Greater reduction in female suicide rates in intervention region compared with control region (IRR =.43). No regional differences in male suicides.
Oyama, Ono et. al, 2006(14) Educational intervention for nurse depression screening and GP management 5-yrs, screening and Depression management Older adults Quasi-experimental* Japan Trend level reduction in female suicide rate in the intervention region (IRR=.26) but not in the control region. No change in male suicide rate.
Henriksson & Isacsson, 2006(18) Yearly 2-day GP training sessions 8-yrs, GP screening and depression treatment Adults Quasi-experimental* Sweden Pre-intervention (1970–1994), suicide rate was higher in Jamtland county than Sweden (p<.05), but during intervention period (19952002) it dropped in intervention region, so the two rates no longer differed.
Szanto et al., 2007(12) Annual educational program for GPs and their nurses 5-yrs, GP supervised depression management Adults Quasi-experimental* Hungary Decrease in suicide rate in intervention region greater than the larger county (p<.001) and Hungary (p<.001).
Alexopoulo s et al., 2009(22) 2-yrs of GP training and case managers 2-yrs with algorithm-based tx advice Older adults RCT## United States Intervention group more likely than to receive antidepressants or psychotherapy (p<.001), and those with major depression had lower rates of SI at 4, 8, and 24 months (p=.04). No difference in SB.
Hegerl et al., 2010(21) 2-Yr, four-level intervention program including GP education 2-yrs, GP depression management Adults Quasi-Experimental* Germany Intervention region had greater reduction in suicidal acts (suicides + SA) (p<.0065) and SA (p<.0005) versus control from baseline to 1-year follow-up of the 2-year intervention (2000–2003). The reduction in SA was more pronounced for high-lethality than low-lethality methods and persisted for four years.
Hübner-Liebermann et al., 2010(19) 5-yrs of four-level intervention program including GP education in depression management 5-yrs, GP depression management Adults Quasi-experimental* Germany The suicide rate declined in the intervention region (p=.02) but not in the control region.
Roškar et al., 2010(27) One-day GP educational program 3-yrs of GP depression management Adults Quasi-Experimental** Slovenia Intervention group had greater increase in antidepressant prescriptions (p<.05) compared with controls but no group differences in suicide rate.
Almeida et al., 2012(26) 2-yrs, GP practice audit with feedback on depression and self-harm, educational materials and control education GP group. 2-yrs of GP depression management Older adults RCT# Australia Intervention group had less self-harm behaviors (0R=.80, p<.05) over 2-yrs.
Hegerl et al., 2019(20) 2-yrs, four-level intervention program including GP training, GP consultation hotline 2-yrs of GP depression treatment Adults Quasi-experimental* Germany, Hungary, Ireland & Portugal In Portugal, the intervention region saw a greater reduction in suicidal acts (suicides + SA) (p=.05) and SA (p=.02) compared with control region. No group differences found in 3 other countries.
*

Studies used a control region as a comparison and examined time periods before and after intervention onset. For such community level intervention studies there were no inclusion or exclusion criteria employed.

**

Study used physicians who did not attend GP training as control group for two regions and had one region as additional control, pre-post intervention time periods were examined.

OR=Odds Ratio; IRR= incidence rate ratio; tx = treatment

#

General Practitioner Inclusion Criteria: on a list provided by Australasian Medical Publishing Company, worked at least 2 days per week, had at least 50 patients aged 60+ who spoke English, and were not planning to retire or move practice within the next two years. Sample size: GP N=373 (with N=21,762 patients aged 60+), intervention GP N=188 (N= 11,402 patients aged 60+), control GP N=185 (N= 10,360 patients aged 60+).

##

Patient Inclusion Criteria: treated at one of the 20 primary care practices participating in the study, aged 60+, met DSM-IV criteria for major or minor depression, defined as 3–4 depressive symptoms, score on the 24-item Hamilton Depression Rating Scale (HAM-D) ≥10, and a duration of at least 1 month. Sample size: Patients N=599, intervention N=320, control N=279.