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. 2022 Apr 27;13:814548. doi: 10.3389/fimmu.2022.814548

Table 3.

Factors associated with CRS severity post CAR-T cells infusion on univariable and multivariable analysis.

Variable Mild CRS Severe CRS Univariate Analysis Multivariable Analysis
OR P OR P
N (%) 47 (87) 7 (13)
Age (range) 59 (53 to 63) 56 (45 to 57) 0.147 0.086 0.899 0.902
Male sex — no. (%) 24 (51) 4 (57) 0.783 0.764
Type of myeloma 0.789
Extramedullary disease, n (%) 14 (30) 1 (14) 0.393 0.407
Number of prior lines of therapy (range) 4 (3 to 5) 4 (3 to 5) 0.896 0.620
Time from initial MM diagnosis (range) 30 (18 to 51) 32 (15 to 59) 0.996 0.759
Bone marrow tumor burden (range) 20 (5 to 32) 47 (34 to 56) 1.034 0.045 1.046 0.046