Table 3.
Factors associated with CRS severity post CAR-T cells infusion on univariable and multivariable analysis.
| Variable | Mild CRS | Severe CRS | Univariate Analysis | Multivariable Analysis | ||
|---|---|---|---|---|---|---|
| OR | P | OR | P | |||
| N (%) | 47 (87) | 7 (13) | ||||
| Age (range) | 59 (53 to 63) | 56 (45 to 57) | 0.147 | 0.086 | 0.899 | 0.902 |
| Male sex — no. (%) | 24 (51) | 4 (57) | 0.783 | 0.764 | ||
| Type of myeloma | 0.789 | |||||
| Extramedullary disease, n (%) | 14 (30) | 1 (14) | 0.393 | 0.407 | ||
| Number of prior lines of therapy (range) | 4 (3 to 5) | 4 (3 to 5) | 0.896 | 0.620 | ||
| Time from initial MM diagnosis (range) | 30 (18 to 51) | 32 (15 to 59) | 0.996 | 0.759 | ||
| Bone marrow tumor burden (range) | 20 (5 to 32) | 47 (34 to 56) | 1.034 | 0.045 | 1.046 | 0.046 |