Table 1:

Illness categories and corresponding treatment approaches for SOT recipients with COVID-19.

Patient presentation	Symptoms, Indication	Therapy Options
Mild illness	Symptoms of upper and/or lower respiratory tract infection in patients who have no hypoxia (SpO2 > 94%)	• Supportive care • For outpatients, consider monoclonal antibodies • Avoid corticosteroids if no oxygen requirement • Consider no change in chronic immunosuppression
Moderate illness	SpO2 <94% on room air or requiring supplemental oxygen	• Hydroxychloroquine should not be used for treatment of COVID-19 • Dexamethasone (or equivalent steroid) 6mg daily for 10 days or upon discharge, whichever comes first • Remdesivir 200 mg ×1 dose, then 100mg daily for 5 days • Consider reducing or holding anti-metabolite
Severe illness	Requiring mechanical ventilation or ECMO	• Dexamethasone as above • Consider remdesivir on a case by case basis, as remdesivir has not been shown to be associated with clinical improvement in patients requiring mechanical ventilation of ECMO • Consider tocilizumab on a case by case basis such as rapidly worsening oxygen requirements and admission to the ICU within 24 hours • Reduce or hold anti-metabolite

SpO2 = peripheral oxygen saturation, ICU = intensive care unit