Fig. 4.

Loss of peripheral integrin αV is associated with poor prognosis in human breast tumors. Kaplan-Meier survival analyses for patients with breast cancer stratified by negative (n=225, red) or positive (n=113, blue) staining for peripheral integrin αV: A) For overall survival (OS), no statistical differences were found between the groups (p=0.164). However, in B) the cancer specific survival (CSS) plot shows that patients with loss of peripheral expression of integrin αV had a worse prognosis when compared to those who maintained integrin αV in the periphery of the lesion clusters (p=0.042). For the disease-free survival (DFS) KM plot C), we did not observe statistical differences (p=0.060), although a trend of greater incidence of metastases can be observed in patients with no peripheral integrin αV. For D) Distant disease-free survival (DDFS), no significant differences were detected between the groups (p=0.439).