Fig. 8.

Presence of stromal integrin αV is associated with metastasis incidence and poor prognosis in human breast tumors. Kaplan-Meier survival curves stratified breast cancer patients of our cohort in negative stromal integrin αV (n=182, red) or positive (n=156, blue): A) For overall survival (OS) no statistical differences were found between the groups (p=0.052). However, in B) the cancer specific survival (CSS) plot shows that patients with positive stromal integrin αV had a worse prognosis when compared to negative stromal integrin αV (p=0.017). Following this trend, we also observe that stromal integrin αV not only worsens the incidence of recurrence C), represented by disease-free survival (DFS) (p=0.024), but also metastases incidence D), showed as distant disease-free survival (DDFS) (p=0.036).