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. 2022 Apr 27;13:878135. doi: 10.3389/fphar.2022.878135

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Copyright © 2022 Du, Yuan, Xu, Zhao, Wang, Xu and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular activity of siRNA mediated METTL3 knockdown and METTL3 inhibitor quercetin in MIA PaCa-2 cells. (A) Results of m⁶A content in mRNA from MIA PaCa-2 cells after transfection with siMETTL3, siNC or non-transfected cells (control), n = 4. (B) Results of m⁶A content in mRNA from MIA PaCa-2 cells after 24 h treatment with the indicated quercetin concentrations, n = 3. Data are mean ± SD. #, p < 0.05; ##, p < 0.01, ns, not significant.