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Model of compound 15c and fragment 1 in the active site of Mac1. Compound 15c (A) was docked into the co-crystallized structure with parent compound 1 (B). Hydrogen bonds are represented as yellow dashes, while pi-pi interactions are represented as cyan dashes. Compound 15c adopts a very similar binding pose to parent compound 1, while orienting the indole into the phosphate binding groove.
