Table 2.

Inhibition data for primary amino acid derivatives. IC₅₀s, changes in the melting temperature and corresponding SDs of three replicates are listed.

Compound	Structure	R group	SARS CoV2 Mac1 Alpha (μM)	Δ Tm (°C) @300 µM
15d			>300
14a		Et	45 ± 0.7
15a		H	24 ± 0.3
14b		Et	Inactive
15b		H	>300
14c		Me	43.9 ± 1.2	0.79 ± 0.11
15c		H	6.1 ± 0.021	4.32 ± 0.14
18		Me	30 ± 0.4	1.51 ± 0.07
19		H	25.2 ± 0.2	1.1 ± 0.21
20		NA	43 ± 5.3