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. 2022 Apr 11;96(9):e00111-22. doi: 10.1128/jvi.00111-22

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FIG 1 — Structural impact of phosphomimetic mutation S210E on Nishigahara P_CTD. (A) Overlay of the wild-type P_CTD from Nishigahara (yellow) and from CVS (salmon; 1VYI). Small structural differences are observed, particularly where Ni-P_CTD has a shorter N terminus. Elements of regular secondary structure are labeled. (B) The two monomers of the crystal unit for S210E P_CTD. (C) Overlay of the wild-type P_CTD from Nishigahara (yellow) and S210E (cyan). The panel on the right is a rotation of 90° around the x axis. Side chains of the C-NES (L224, F227, L230, and M232) and the C-NLS (K211, K212, K214, and R260), as well as the site of mutation (S210E), are shown for wild-type (yellow) and S210E (magenta) P_CTD. The change in interaction of N226 for E228 in wild-type (yellow) for E210 (magenta) in S210E is highlighted in the expansion in panel D.