Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The N6-methyladenosine (m6A) methyltransferase complex (MTC) that includes METTL3 methylates intracisternal A particle (IAP) mRNA and heterochromatic RNA (hetRNA). Binding of m6A by Ythdc1 is essential for the downstream deposition of H3K9me3 by Setdb1/Trim28. Methylated hetRNA associates with chromatin and facilitates the retention of HP1 and Suv39h proteins. H3K9me3, HP1, hetRNA, and Suv39h are lost upon Mettl3 depletion.
