Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 27;13:884275. doi: 10.3389/fgene.2022.884275

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Aisagbonhi and Morris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HLA molecules in preeclampsia. HLA-G levels are decreased in preeclampsia which evidence suggest result in defects in tolerance induction and spiral artery remodeling. Though disputed by some studies, most studies suggest that HLA-C engaging inhibitory KIR receptors on NK cells (such as KIR2DL1) also leads to defects in spiral artery remodeling as failed NK cell release of pro-migratory chemokines and cytokines limits EVT invasion. The roles of HLA-E and HLA-F in preeclampsia need to be investigated further.