Table 3.
Correlation of SMARCA2 negative expression with clinicopathological features in 2390 cases with NSCLC.
| Total n (%) | Expression of SMARCA2 | P-value | χ2 | ||
|
| |||||
| Positive n (%) | Negative n (%) | ||||
| Age-years | 2390 | 2168 | 222 | ||
| ≤60 | 1018(42.6) | 930(42.9) | 88(39.6) | 0.349 | 0.874 |
| >60 | 1372(57.4) | 1238(57.1) | 134(60.4) | ||
| Gender | 2390 | 2168 | 222 | ||
| Male | 1077(45.1) | 952(43.9) | 125(56.3) | 4.076E-04* | 12.497 |
| Female | 1313(54.9) | 1216(56.1) | 97(43.7) | ||
| Smoking history | 2390 | 2168 | 222 | ||
| Yes | 568(23.8) | 507(23.4) | 61(27.5) | 0.173 | 1.861 |
| No | 1822(76.2) | 1661(76.6) | 161(72.5) | ||
| Emphysema/Tuberculosis | 2390 | 2168 | 222 | ||
| Yes | 77(3.2) | 66(3.0) | 11(95.0) | 0.125 | 2.358 |
| No | 2313(96.8) | 2102(97.0) | 211(5.0) | ||
| Family history | 2390 | 2168 | 222 | ||
| Yes | 295(12.3) | 267(12.3) | 28(12.6) | 0.898 | 0.016 |
| No | 2095(87.7) | 1901(87.7) | 194(87.4) | ||
| Tumor location | 2390 | 2168 | 222 | ||
| Central | 160(6.7) | 146(6.7) | 14(6.3) | 0.808 | 0.059 |
| Peripheral | 2230(93.3) | 2022(93.3) | 208(93.7) | ||
| Different lung lobes | 2390 | 2168 | 222 | ||
| Middle lobe | 196(8.2) | 169(7.8) | 27(12.2) | 0.024* | 5.101 |
| Upper & lower lobe | 2194(91.8) | 1999(92.2) | 195(87.8) | ||
| Tumor size | 2390 | 2168 | 222 | ||
| <2 cm | 1125(47.1) | 1064(49.1) | 61(27.5) | 8.201E-10* | 37.712 |
| ≥2 cm | 1265(52.9) | 1104(50.9) | 161(72.5) | ||
| T-stage | 2390 | 2168 | 222 | ||
| T1 | 1627(68.1) | 1514(69.8) | 113(50.9) | 1.465E-10* | 48.763 |
| T2 | 647(27.1) | 565(26.1) | 82(36.9) | ||
| T3 | 67(2.8) | 49(2.3) | 18(8.1) | ||
| T4 | 49(2.0) | 40(1.8) | 9(4.1) | ||
| N-stage | 2390 | 2168 | 222 | ||
| N0 | 2007(84.0) | 1849(85.3) | 158(71.2) | 4.757E-08* | 29.814 |
| N+ | 383(16.0) | 319(14.7) | 64(28.8) | ||
| M-stage | 2390 | 2168 | 222 | ||
| M0 | 2371(99.2) | 2151(99.2) | 220(99.1) | 1.000 | 2.983E-28 |
| M+ | 19(0.8) | 17(0.8) | 2(0.9) | ||
| TNM Stage (UICC/AJCC 8th) |
2390 | 2168 | 222 | ||
| I | 1897(79.4) | 1758(81.1) | 139(62.6) | 2.556E-09* | 42.923 |
| II | 194(8.1) | 161(7.4) | 33(14.9) | ||
| III | 280(11.7) | 232(10.7) | 48(21.6) | ||
| IV | 19(0.8) | 17(0.8) | 2(0.9) | ||
| Pleural invasion | 2390 | 2168 | 222 | ||
| Yes | 523(21.9) | 449(20.7) | 74(33.3) | 1.474E-05* | 18.771 |
| No | 1867(78.1) | 1719(79.3) | 148(66.7) | ||
| Vascular invasion | 2390 | 2168 | 222 | ||
| Yes | 120(5.0) | 98(4.5) | 22(9.9) | 4.612E-04* | 12.266 |
| No | 2270(95) | 2070(95.5) | 200(90.1) | ||
| STAS | 2390 | 2168 | 222 | ||
| Yes | 155(6.5) | 141(6.5) | 14(6.3) | 0.909 | 0.013 |
| No | 2235(93.5) | 2027(93.5) | 208(93.7) | ||
| Necrosis | 2390 | 2168 | 222 | ||
| Yes | 228(9.5) | 189(8.7) | 39(17.6) | 1.911E-05* | 18.276 |
| No | 2162(90.5) | 1979(91.3) | 183(82.4) | ||
| Differentiation states | 2386 | 2164 | 222 | ||
| Well | 592(24.8) | 577(26.7) | 15(6.8) | <2.200E-16* | 84.030 |
| moderate | 923(38.7) | 856(39.5) | 67(30.2) | ||
| Poor | 871(36.5) | 731(33.8) | 140(63.0) | ||
| Ki-67 | 2389 | 2167 | 222 | ||
| <15% | 1177(49.3) | 1114(51.4) | 63(28.4) | 6.294E-11* | 42.727 |
| ≥15% | 1212(50.7) | 1053(48.6) | 159(71.6) | ||
| P53 | 2388 | 2166 | 222 | ||
| Aberrant | 720(30.2) | 632(29.2) | 88(39.6) | 1.217E-03* | 10.464 |
| WT | 1668(69.8) | 1534(70.8) | 134(60.4) | ||
| SOX-2 | 2390 | 2168 | 222 | ||
| Positive | 683(28.6) | 638(29.4) | 45(20.3) | 0.004* | 8.274 |
| Negative | 1707(71.4) | 1530(70.6) | 177(79.7) | ||
| PD-L1 | 2386 | 2164 | 222 | ||
| ≤1% | 1987(83.3) | 1818(84.0) | 169(76.1) | 0.003* | 11.633 |
| 1%–50% | 186(7.8) | 166(7.7) | 20(9.0) | ||
| ≥50% | 213(8.9) | 180(8.3) | 33(14.9) | ||
| EGFR | 569 | 504 | 65 | ||
| MT | 270(47.5) | 237(47.0) | 33(50.8) | 0.569 | 0.324 |
| WT | 299(52.5) | 267(53.0) | 32(49.2) | ||
| ALK | 2390 | 2168 | 222 | ||
| Positive | 40(1.7) | 37(1.7) | 3(1.4) | 0.906 | 0.014 |
| Negative | 2350(98.3) | 2131(98.3) | 219(98.6) | ||
| Classification | 2390 | 2168 | 222 | ||
| AD | 2174(91.0) | 1969(90.8) | 205(92.3) | 0.003* | 11.777 |
| SCC | 200(8.4) | 188(8.7) | 12(5.4) | ||
| Others | 16(0.6) | 11(0.5) | 5(2.3) | ||
Note: *P < 0.05; STAS: spread through air spaces; WT: Wild type; MT: Mutant type.