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. 2022 Apr 27;10:885440. doi: 10.3389/fcell.2022.885440

FIGURE 3.

FIGURE 3

Schematic illustrations of representative cp and ncp FP-based indicators. (A) An ncp FP-based indicator is constructed by inserting a binding domain into an FP. Examples of ncp FP-based indicators include camgaroo (Baird et al., 1999), NCaMP7 (Subach et al., 2020), NIR-GECO1 (Qian et al., 2019), ZnGreen1 (Chen and Ai, 2016), ZIBG1 (Chen et al., 2019), ZnRed (Chen and Ai, 2016), and GINKO (Shen et al., 2019). (B) A cp FP-based indicator is constructed by inserting a cp FP into a binding domain or by fusing two interacting motifs to the termini of the cp FP. The cpFP indicators include pericam (Nagai et al., 2001), GCaMP (Chen et al., 2013; Dana et al., 2019), G-GECO (Zhao et al., 2011), R-GECO (Zhao et al., 2011), O-GECO (Wu et al., 2013), RCaMP (Akerboom et al., 2013), K-GECO (Zhao et al., 2011), mNG-GECO (Zarowny et al., 2020), ZnGreen2 (Chen and Ai, 2016), and ZIBG2 (Chen et al., 2019).