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. 2022 Apr 27;10:885440. doi: 10.3389/fcell.2022.885440

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Copyright © 2022 Wu, Shen, Shkolnikov and Campbell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular structures of selected small molecule-based K⁺ indicators (PBFI and Potassium Green 2) and schematic representations of selected GEKIs. Small molecule-based K⁺ indicators (A) PBFI and (B) Asante Potassium Green 2 (APG-2) are based on 1, 10-diaza-4, 7, 13, 16-tetraoxacyclopentadecane (Minta and Tsien, 1989; Rimmele and Chatton, 2014). (C) FRET-based KIRIN and GEPII are based on Kbp that consists of a BON and a LysM domain (Ashraf et al., 2016; Shen et al., 2019). (D) GINKO1 and GINKO2 are based on Kbp and ncpEGFP (Shen et al., 2019; Wu et al., 2021).