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. 2022 Apr 27;12:889159. doi: 10.3389/fonc.2022.889159

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Copyright © 2022 Long, Wang, Weng, Xiang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ECM1 regulates CRC cell EMT induction. EMT-related protein expression was analyzed following the knockdown or upregulation of ECM1. (A–C) Vimentin and E-cadherin protein levels were assessed in HCT15, HCT15-NC, and HCT15-siECM1 cells. (D–F) Vimentin and E-cadherin protein levels were investigated in HCT116, HCT116-NC, and HCT116-ECM1 cells. Data are means± SD (**P < 0.01, ***P < 0.001).